Table 1 |
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|
Antiviral activity of BPR1P0034. |
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|
Concentration (μM) |
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|
|
||||
|
BPR1P0034 |
Amantadine |
Zanamivir |
||
|
|
|
|||
|
IC50 |
CC50c |
IC50 |
IC50 |
|
|
|
||||
|
Cytotoxic effect |
||||
|
MDCK |
6.75 ± 0.08 |
|||
|
Influenza virus |
||||
|
A/WSN/33 (H1N1)b |
0.21 ± 0.07 |
> 25 |
0.06 ± 0.02 |
|
|
A/Udorn/72 (H3N2)a |
2.11 ± 0.41 |
0.98 ± 0.15 |
0.67 ± 0.23 |
|
|
A/TW/83/05 (H3N2)a |
1.38 ± 0.08 |
> 25 |
0.92 ± 0.03 |
|
|
A/TW/785/05 (H1N1)a |
0.92 ± 0.11 |
0.38 ± 0.24 |
1.06 ± 0.98 |
|
|
B/TW/710/05b |
8.11 ± 3.98 |
> 25 |
0.03 ± 0.02 |
|
|
B/TW/70325/05b |
1.94 ± 0.72 |
> 25 |
0.02 ± 0.01 |
|
|
B/TW/99/07b |
8.90 ± 4.16 |
> 25 |
0.10 ± 0.01 |
|
|
Enterovirus 71b |
||||
|
TW/1743/98 |
> 40 |
> 20 |
-- |
-- |
|
TW/4643/98 |
> 20 |
> 20 |
-- |
-- |
|
Echovirus 9b |
> 20 |
> 20 |
-- |
-- |
|
|
||||
|
MDCK cells or Vero cells were infected with influenza virus and EV71, respectively, and incubated with different concentrations of BPR1P0034. IC50was determined with a plaque reduction assaya or a neutralization assayb cCC50 was determined with an MTT assay --, not determined The values are means ± SD of 2--3 independent experiments. |
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|
Shih et al. Journal of Biomedical Science 2010 17:13 doi:10.1186/1423-0127-17-13 |
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