Table 2

Cellular proteins involved in picornaviral IRES-mediated translation

Proteins

Binding sites/associated viral proteins

Viruses

Refs

PTB

IRES, 3C

PV, HRV, EMCV, FMDV, TMEV, HAV

[130-136]

nPTB

IRES

PV, TMEV

[135,143]

PCBP1

Cloverleaf, IRES

PV, HRV

[93,153]

PCBP2

Cloverleaf, IRES, 2A, 3CD, 3C

PV, HRV, HAV, CVB3

[94,152-154,156,170]

Unr

IRES

PV, HRV

[139,157]

La

IRES, 3C

PV, HRV, HAV, CVB3, EMCV

[147,148,150,151,171]

ITAF45

IRES

FMDV

[124]

hnRNP A1

IRES

HRV2, EV71

[158,159]

Nucleolin/C23

IRES

PV, HRV

[162]

DRBP 76: NF45 heterodimer

IRES

HRV2

[163,164]

GAPDH

IRES

HAV

[137,172]

FBP2

IRES

EV71

[168]

PABP

IRES

PV, EMCV

[125,173]

*PTB, polypyrimidine tract-binding protein; nPTB, neural polypyrimidine tract-binding protein; PCBP, poly(rC) binding protein; Unr, upstream element binding protein; La, Lupus autoantigen; hnRNP, heterogeneous nuclear ribonucleoprotein; DRBP 76: NF45 heterdimer, dsRNA binding protein 76: NF45 heterdimer; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; FBP2, far upstream element binding protein 2; PABP, poly(A)-binding protein.

Lin et al. Journal of Biomedical Science 2009 16:103   doi:10.1186/1423-0127-16-103