Email updates

Keep up to date with the latest news and content from Journal of Biomedical Science and BioMed Central.

MST logoThe cost of publication in Journal of Biomedical Science is borne by the Ministry of Science and Technology, Taiwan.

Open Access Highly Accessed Review

Impact of cellular autophagy on viruses: Insights from hepatitis B virus and human retroviruses

Sai-Wen Tang1, Aurelie Ducroux2, Kuan-Teh Jeang1* and Christine Neuveut2*

Author Affiliations

1 Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892-0460, USA

2 Laboratory of Hepacivirus and Innate Immunity, Institut Pasteur, 75015, Paris, France

For all author emails, please log on.

Journal of Biomedical Science 2012, 19:92  doi:10.1186/1423-0127-19-92

Published: 30 October 2012

Abstract

Autophagy is a protein degradative process important for normal cellular metabolism. It is apparently used also by cells to eliminate invading pathogens. Interestingly, many pathogens have learned to subvert the cell’s autophagic process. Here, we review the interactions between viruses and cells in regards to cellular autophagy. Using findings from hepatitis B virus and human retroviruses, HIV-1 and HTLV-1, we discuss mechanisms used by viruses to usurp cellular autophagy in ways that benefit viral replication.