Figure 5.

The expressions of ER stress chaperones. Upregulation of mRNA and protein expression of Bip, PERK and CHOP were caused by hypoxia in the testes and were attenuated by CPU86017-RS and Nif. A, Bip mRNA; B, Bip protein; C, PERK mRNA; D, PERK protein; E, CHOP mRNA; F, CHOP protein. Mean ± SD, n = 10. *P < 0.05, **P < 0.01, vs. Normal; ^#P < 0.05, ^{# #}P < 0.01, vs. Hypoxia, ^$P < 0.05, vs. H+RSL (hypoxia + RS low dose).