Antibiotic pretreatment with subsequent E.coli intratracheal injection induced an increase of mortality and LPS supplementation decreased it in C3H/HeN mice. However, in E.coli-treated C3H/HeJ mice, antibiotic pretreatment did not induce mortality. * p < 0.05, vs. commensal depletion + E.coli group (n = 15 per group).
Tsay et al. Journal of Biomedical Science 2011 18:68 doi:10.1186/1423-0127-18-68