The cost of publication in Journal of Biomedical Science is borne by the National Science Council, Taiwan.
Review
Fish-on-a-chip: a sensitive detection microfluidic system for alzheimer's disease
-
* Corresponding authors: Sanghyo Kim samkim@kyungwon.ac.kr - Jeongho An jhahn1us@skku.edu
1 College of Bionanotechnology, Kyungwon University, San 65, Bokjeong-Dong, Sujeong-Gu, Seongnam-Si, Gyeonggi-Do 461-701, Republic of Korea
2 Department of Polymer Science & Engineering, SungKyunKwan University, Suwon, Gyeonggi-do 440-146, South Korea
Journal of Biomedical Science 2011, 18:33 doi:10.1186/1423-0127-18-33
Published: 28 May 2011Abstract
Microfluidics has become an important tool in diagnosing many diseases, including neurological and genetic disorders. Alzheimer's disease (AD) is a neurodegenerative disease that irreversibly and progressively destroys memory, language ability, and thinking skills. Commonly, detection of AD is expensive and complex. Fluorescence in situ hybridization (FISH)-based microfluidic chip platform is capable of diagnosing AD at an early stage and they are effective tools for the diagnosis with low cost, high speed, and high sensitivity. In this review, we tried to provide basic information on the diagnosis of AD via FISH-based microfluidics. Different sample preparations using a microfluidic chip for diagnosis of AD are highlighted. Moreover, rapid innovations in nanotechnology for diagnosis are explained. This review will provide information on dynamic quantification methods for the diagnosis and treatment of AD. The knowledge provided in this review will help develop new integration diagnostic techniques based on FISH and microfluidics.