The cost of publication in Journal of Biomedical Science is borne by the National Science Council, Taiwan.
Composition and conservation of the mRNA-degrading machinery in bacteria
- Equal contributors
1 Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan
2 Department of Immunology, Microbiology and Parasitology, University of the Basque Country, UPV/EHU, Leioa, Spain
3 IKERBASQUE, Basque Foundation for Science, 48011, Bilbao, Spain
Journal of Biomedical Science 2011, 18:23 doi:10.1186/1423-0127-18-23Published: 22 March 2011
RNA synthesis and decay counteract each other and therefore inversely regulate gene expression in pro- and eukaryotic cells by controlling the steady-state level of individual transcripts. Genetic and biochemical data together with recent in depth annotation of bacterial genomes indicate that many components of the bacterial RNA decay machinery are evolutionarily conserved and that their functional analogues exist in organisms belonging to all kingdoms of life. Here we briefly review biological functions of essential enzymes, their evolutionary conservation and multienzyme complexes that are involved in mRNA decay in Escherichia coli and discuss their conservation in evolutionarily distant bacteria.