Table 4 |
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|
Combined effect of arsenic exposure and HO-1 genotype on the risk of carotid atherosclerosis. |
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|
Combination of arsenic exposure, μg/L and HO-1 genotype |
Controls n (%) |
Patients n (%) |
Multivariate-adjusted OR (95% CI) |
OR changes for carriers vs. non-carriers of the class S allele, % |
|
|
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|
Lanyang cohorta |
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|
≤ 50, Non-carriers of the class S allele |
8 (3.1) |
6 (2.4) |
1.00 |
(Reference) |
|
≤ 50, Carriers of the class S allele |
20 (7.8) |
12 (4.8) |
0.60 (0.15-2.45) |
-40.0 |
|
50-100, Non-carriers of the class S allele |
21 (8.2) |
24 (9.6) |
1.49 (0.39-5.69) |
(Reference) |
|
50-100, Carriers of the class S allele |
66 (25.8) |
64 (25.6) |
1.38 (0.40-4.80) |
-7.4 |
|
100-300, Non-carriers of the class S allele |
19 (7.4) |
20 (8.0) |
1.72 (0.44-6.70) |
(Reference) |
|
100-300, Carriers of the class S allele |
60 (23.4) |
61 (24.4) |
1.37 (0.39-4.79) |
-20.3 |
|
> 300, Non-carriers of the class S allele |
17 (6.6) |
22 (8.8) |
1.48 (0.38-5.77) |
(Reference) |
|
> 300, Carriers of the class S allele |
45 (17.6) |
41 (16.4) |
1.14 (0.32-4.08) |
-23.0 |
|
LMN cohortb |
||||
|
≤ 300, Non-carriers of the class S allele |
13 (7.9) |
2 (1.7) |
1.00 |
(Reference) |
|
≤ 300, Carriers of the class S allele |
39 (23.8) |
10 (8.6) |
0.49 (0.07-3.32) |
-51.0 |
|
300-750, Non-carriers of the class S allele |
22 (13.4) |
20 (17.1) |
1.13 (0.18-7.16) |
(Reference) |
|
300-750, Carriers of the class S allele |
43 (26.2) |
36 (30.8) |
1.02 (0.17-6.10) |
-9.7 |
|
> 750, Non-carriers of the class S allele |
10 (6.1) |
14 (12.0) |
4.45 (0.64-30.93) |
(Reference) |
|
> 750, Carriers of the class S allele |
37 (22.6) |
35 (29.9) |
1.09 (0.18-6.64) |
-75.5* |
|
|
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|
OR: odds ratio; CI: confidence interval. a Adjusted for age, sex, logarithm triglyceride, total cholesterol, and hypertension history. b Adjusted for age, sex, hypertension history, and diabetes history. Age, triglyceride, and cholesterol were defined as continuous variables in the regression models. The class S allele denotes <27 GT repeats and L allele ≥27 GT repeats in the HO-1 gene promoter. * p = 0.051 for the OR difference between carriers vs. non-carriers of the class S allele at arsenic exposure level >750 μg/L. |
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|
Wu et al. Journal of Biomedical Science 2010 17:70 doi:10.1186/1423-0127-17-70 |
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