Table 1 |
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|
PD candidate genes. |
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|
Gene Name |
Accession No. |
Symbol |
Screen |
Position |
Locus |
|
|
|
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|
1 |
Tetraspanin 6 |
Tspan6 |
Chung et al. |
Xq22.1 |
PARK 12 |
|
|
|
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|
2 |
ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast) |
UBE2K |
Chung et al. |
4p14 |
PARK 5 |
|
|
|
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|
3 |
Ribosomal protein L11 |
RPL11 |
Chung et al. |
1p36.1-p35 |
PARK 6 & 7 |
|
|
|
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|
4 |
Ribosomal protein L36a |
RPL36A |
Chung et al. |
Xq22.1 |
PARK 12 |
|
|
|
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|
5 |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 |
SMARCA1 |
Chung et al. |
Xq25 |
PARK 12 |
|
|
|
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|
6 |
MARCKS-like 1 |
MARCKSL1 |
Chung et al. |
1p35.1 |
PARK 6 |
|
|
|
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|
7 |
GTPase activating protein 24 |
ARHGAP24 |
Chung et al. |
4q21.23-4q21.3 |
PARK 4 |
|
|
|
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|
8 |
F-box only protein 2 |
FBXO2 |
Chung et al. |
1p36.22 |
PARK 7 |
|
|
|
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|
9 |
T-complex-associated-testis-expressed 1-like |
DYNLT3 |
Chung et al. |
Xp21 |
PARK 12 |
|
|
|
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|
10 |
Cyclin I |
CCNI |
Chung et al. |
4q21.1 |
PARK 4 |
|
|
|
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|
11 |
Solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 |
SLC25A5 |
Chung et al. |
Xq24-q26 |
PARK 12 |
|
|
|
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|
12 |
Pyruvate dehydrogenase E1 alpha 1 |
PDHA1 |
Greene et al. |
Xp22.12 |
PARK 12 |
|
|
|
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|
13 |
Ubiquitin carboxy-terminal hydrolase L1 PARK |
UCHL1 |
Greene et al. |
4p14 |
PARK 5 |
|
|
|
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|
14 |
G protein-coupled receptor, family C, group 5, member A |
GPRC5A |
Grimm et al. |
12p13.1 |
PARK 8 |
|
|
|
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|
15 |
Protein tyrosin phosphatase, receptor type, U |
PTPRU |
Grimm et al. |
1p35.3 |
PARK 6 |
|
|
|
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|
16 |
Klech-like 13 (drosophila) |
KLHL13 |
Grimm et al. |
Xq24 |
PARK 12 |
|
|
|
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|
17 |
Dehyrogenase/reductase (SDR family) member 3 |
DHRS3 |
Grimm et al. |
1p36.22-1p36.21 |
PARK 7 |
|
|
|
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|
18 |
NEL-like 2 (chicken) |
NELL2 |
Grimm et al. |
12q13.11-q13.12 |
PARK 8 |
|
|
|
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|
19 |
Serin (or cysteine) peptidase inhibitor clade B, member 6a |
SERPINB6 |
Grimm et al. |
6q25 |
PARK 2 |
|
|
|
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|
20 |
Peripherin 1 |
PRPH |
Grimm et al. |
12q12-q13 |
PARK 8 |
|
|
|
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|
The list of genes, with ISH-detectable expression in midbrain dopaminergic neurons, with cytogenetic locations, falling within PARK loci are shown. Numbers 1,4,5,9,11,12 and 16 are within PARK-12, an orphan PD locus and UCHL1 (13) is a known PD gene. |
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|
Vahedi et al. Journal of Biomedical Science 2010 17:66 doi:10.1186/1423-0127-17-66 |
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