Table 6

Effects of ischemia-hypoxia and ischemia-hyperoxia in the hippocampus of aged rats

Ischemia-hypoxia

Ischemia-hyperoxia

Metabolite

Control

Right

Left

Right

Left

Alanine

0.91 ± 0.12

0.37 ± 0.05*

0.38 ± 0.07*

1.28 ± 0.36

1.01 ± 0.23

Choline

4.27 ± 0.08

2.56 ± 0.40***

2.69 ± 0.18***

4.03 ± 0.28

4.03 ± 0.26

Creatine

12.69 ± 0.32

7.52 ± 0.90*

7.80 ± 0.75**

12.31 ± 0.41

11.68 ± 0.58

GABA

2.65 ± 0.24

1.38 ± 0.39**

1.66 ± 0.23**

3.22 ± 0.48

2.69 ± 0.31

Glutamate

15.53 ± 0.44

6.97 ± 0.96***

6.88 ± 0.48***

12.67 ± 1.40*

13.06 ± 1.00**

Lactate

16.24 ± 0.34

12.69 ± 1.42***

11.38 ± 0.55***

17.05 ± 0.26*

17.03 ± 1.00*

Myo-inositol

8.26 ± 0.45

5.27 ± 1.15*

5.87 ± 0.66**

8.75 ± 0.50

9.01 ± 0.56

N-acetylaspartate

10.51 ± 0.18

6.35 ± 0.45***

6.00 ± 0.42***

9.41 ± 0.37

9.13 ± 0.46

Concentrations of metabolites (mmol/kg w/w) in aged rats, under normoxic condition (control), ischemia-hypoxia, and ischemia-hyperoxia. Data are means ± SE (n = 10 rats/group). Values, determined by proton MRS as outlined in the Methods, are given for the right (ipsilateral to cerebral ischemic injury) and left (contralateral) hemisphere. *P < 0.05, **P < 0.01, and ***P < 0.001 compared with controls.

Macri et al. Journal of Biomedical Science 2010 17:14   doi:10.1186/1423-0127-17-14