Journal of Biomedical Science

official impact factor 1.96

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Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity

Shin-Ru Shih1,3, Tzu-Yun Chu2, Gadarla R Reddy4, Sung-Nain Tseng1,3, Hsiun-Ling Chen2, Wen-Fang Tang2, Ming-sian Wu2, Jiann-Yih Yeh4, Yu-Sheng Chao4, John TA Hsu4,5, Hsing-Pang Hsieh4* and Jim-Tong Horng2,3*

Author Affiliations

1 Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan 333, Taiwan

2 Department of Biochemistry, Chang Gung University, Taoyuan333, Taiwan

3 Research Center for Emerging Viral Infections, Chang Gung University, Taoyuan 333, Taiwan

4 Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli 350, Taiwan

5 Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 300, Taiwan

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Journal of Biomedical Science 2010, 17:13 doi:10.1186/1423-0127-17-13

Published: 23 February 2010

Additional files

Additional file 1:

Supplementary materials and methods. General synthesis of BPR1P series-reagents and conditions.

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Additional file 2:

Supplementary table. Lead optimization by SAR study.

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