Table 2 |
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|
Functional Polymorphism of MMP-1(-16071G/2G), MMP-2 (-1306 C>T), MMP-3 (-1171 5A/6A) MMP-9 (P574R C>G;-1562 C>T) and TIMP-2 (-418 GC or CC) in potentially malignant and malignant head- and neck malignancies |
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|
Study |
Country |
Year |
MMPs type |
Mode of detection |
Polymorphism |
Case/Control group |
OR |
95%CI |
p-value |
Tumour |
|
|
||||||||||
|
Chaudhary et al [57] |
India |
2010 |
MMP-3 |
PCR-RFLP |
-1171 5A/6A |
101/126 135/126 |
2.26 1.94 |
1.22-4.20 1.06-3.51 |
0.01 0.03 |
HNSCC OSMF |
|
|
||||||||||
|
Shimizu et al [36] |
Japan |
2008 |
MMP-1 IL-8 |
PCR-RFLP, IHC |
-1607 1G/2G IL-8-251 A/A |
- |
- - |
- - |
0.001 0.003 |
TSCC |
|
|
||||||||||
|
Wu et al [61] |
China |
2008 |
MMP-9 |
PCR-RFLP |
P574R C>G |
- |
4.1 |
1.58-10.52 |
0.00 |
ESCC |
|
|
||||||||||
|
Tu et al [62] |
Taiwan |
2007 |
MMP-9 |
PCR-RFLP |
-1562 C>T |
192/191 73/191 |
- |
- |
0.029 |
OSCC OSMF |
|
|
||||||||||
|
Nasr et al [38] |
North Africa |
2007 |
MMP-9 MMP-1 |
PCR-RFLP |
-1562 C/T -1607 1G/2G |
174/171 |
- 2.9 |
- |
- 0.02 |
- NPC |
|
|
||||||||||
|
Vairaktaris et al [63] |
Greece |
2008 |
MMP-9 |
PCR-RFLP |
-1562 C/T |
152/162 |
1.9 |
1.21-3.06 |
0.05 |
OSCC |
|
|
||||||||||
|
Vairaktaris et al [55] |
Greece |
2007 |
MMP-3 MMP-1 |
PCR-RFLP |
-1171 5A/6A -1607 1G/2G |
160/156 141/156 |
2.2 - |
1.0-4.5 - |
< 0.05 < 0.05 |
OSCC |
|
|
||||||||||
|
Nishizawa et al [37] |
Japan |
2007 |
MMP-1 MMP-3 |
PCR-RFLP |
-1607 1G/2G -1171 5A/6A |
170/164 |
2.4 - |
1.5-4.6 - |
0.000 - |
OSCC |
|
|
||||||||||
|
O-Charoenrat and Khantapura [51] |
Thailand |
2006 |
TIMP-2 MMP-2 |
PCR-RFLP |
-418GC or CC -1306C-->T |
239/250 239/250 |
1.43 1.97 |
0.98-2.08 1.23-3.15 |
- - |
HNSCC |
|
|
||||||||||
|
Tu et al [56] |
Taiwan |
2006 |
MMP-3 |
PCR-RFLP |
-1171 5A/6A |
150/98 71/98 |
1.7 2.62 |
0.84-3.445 1.20-5.71 |
0.18 0.01 |
OSCC OSF |
|
|
||||||||||
|
Cao and Li [41] |
China |
2006 |
MMP-1 |
PCR-RFLP |
-1607 1G/2G |
96/120 |
2.2 |
1.5-3.4 |
0.000 |
OSCC |
|
|
||||||||||
|
Zinzindohoue et al [42] |
France |
2004 |
MMP-1 MMP-3 |
PCR-RFLP |
-1607 1G/2G -1171 5A/6A |
126/249 |
0.37 - |
0.2-0.7 - |
0.003 - |
HNSCC |
|
|
||||||||||
|
Lin et al [52] |
Taiwan |
2004 |
MMP-2 |
PCR & dHPLC |
-1306 C>T |
121/147 58/147 |
2.0 |
- |
- |
OSCC OSF |
|
|
||||||||||
|
Hashimoto et al [44] |
Japan |
2004 |
MMP-1 MMP-3 |
PCR-RFLP |
-1607 1G/2G -1171 5A/6A |
140/223 |
1.6 NS |
- - |
0.04 NS |
HNSCC |
|
|
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|
[PCR-RFLP = Polymerase chain reaction-fragment length polymorphism, dHPLC = Denaturing high-performance liquid chromatography, ESCC = Esophageal squamous cell carcinoma, BSCC = Buccal squamous cell carcinoma, OSCC = Oral squamous cell carcinoma, OSMF = Oral sub-mucous fibrosis, NPC = Nasopharyngeal carcinoma, HNSCC = Head and neck squamous cell carcinoma, TC = Tongue squamous cell Carcinoma, NS = Not significant] |
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|
Chaudhary et al. Journal of Biomedical Science 2010 17:10 doi:10.1186/1423-0127-17-10 |
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