Figure 6.

Far UV CD spectra of the histones in 10 mM Tris-HCl at pH 7.3 in the absence and presence of mitoxantrone. Each spectrum was obtained at 25°C with a 10 mm path length cell. 1–4 are 0, 10, 20 and 40 μM of mitoxantrone respectively. All necessary corrections were made for background absorption.