Table 1 |
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Modified biomaterials attempted to promote nerve regeneration. |
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Biomaterials |
Modification/Method of fabrication |
Improved Properties |
Ref |
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|
Star-Poly(ethylene glycol) |
Incorporation of polysaccharide (Heparin) |
Tunable physical and mechanical properties to adopt specific tissue requirements |
[62] |
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Chitosan |
Modified with (γ-glycidoxypropyltrimethoxysilane (GPTMS) |
Mechanical strength |
[63] |
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Poly(sialic acid) |
Hydrogel modified with adsorbed poly-L-lysine or poly-L-ornithine or laminin or collagen |
Mechano compatibility; Cell adhesive property |
[64] |
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Poly(β-hydroxybutyrate) |
Sheets impregnated with extracellular matrix molecules |
Cell adhesion and proliferation |
[65] |
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Poly(ε-caprolactone) |
Electrospinning and Thermal fiber bonding |
Mechanical strength |
[66] |
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Poly(ε-caprolactone) |
Aligned fibers by Electrospinning |
Contact guidance |
[67] |
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Poly(lactic-co-glycolic acid) |
Modified immersion precipitation method |
Selective permeability; Hydrophilicity |
[68] |
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Poly(D, L-lactide-co-ε-caprolactone) [PDLLA/CL] |
PPy coating substrate and PPy nanoparticle/PDLLA/CL composite |
Electrical cue for multitude of cell functions |
[69] |
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Chitosan |
Polylysine-functionalised thermoresponsive chitosan hydrogel |
Injectable scaffold; Mechano compatibility; Surface property (wettability, charge density) |
[70] |
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Poly(ε-caprolactone) |
Electrospinning (Polymer blending with collagen) |
Biological property (schwann cell adhesion, migration and differentiation) |
[71] |
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Collagen |
Hydrogel crosslinked with YIGSR peptide modified dendrimers |
Biological function (promote the growth of corneal epithelial cells and neurite outgrowth) |
[72] |
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Poly(glycerol-sebacate) |
Replica molding |
Micropatterned substrates; Flexibility; Surface degradable; Strong contact guidance response |
[73] |
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Poly(lactic-co-glycolic acid) |
Microbraiding method |
Flexibility; Porosity |
[75] |
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Poly(D,L-lactide-co-glycolide) |
Low pressure injection molding |
Porosity; Longitudinally aligned channels; Mimics the geometry of native nerves |
[76] |
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Poly(2-hydroxyethyl methacrylate) |
Fiber templating technique |
Oriented scaffold; Physical characteristics similar to soft tissue. |
[77] |
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Poly(2-hydroxyethyl methacrylate) |
Liquid-liquid centrifugal casting |
Mechanical property similar to spinal cord |
[78] |
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Subramanian et al. Journal of Biomedical Science 2009 16:108 doi:10.1186/1423-0127-16-108 |
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